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54–56 In the large intestine, residual quercetin/quercetin glycosides and their conjugates undergo extensive metabolism by the gut microbiota, transforming into various phenolic acids

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For instance, studies have shown that chemotherapeutic agents like melphalan can directly disrupt ileal BA reabsorption (156), while other treatments reduce the abundance of key BA-metabolizing bacteria, such as those within the Clostridiales order